Bioactive Small Molecules
Cayman Chemical ANTIBODY SBP-7455 5mg
A dual inhibitor of ULK1 and ULK2 (IC50s = 13 and 476 nM, respectively, for the recombinant human enzymes in cell-free assays); inhibits increases in autophagic flux and induces apoptosis in serum-deprived MDA-MB-468 breast cancer cells at 10 µM; reduces the viability of MDA-MB-468 cells at 0.19 µM alone or in combination with olaparib
Cayman Chemical ANTIBODY AcefylIn 10mg
An analytical reference standard categorized as a respiratory stimulant; intended for research and forensic applications
Cayman Chemical CRABP IICelular retInoIc a
An active metabolite of thalidomide increases hexobarbitone-induced sleeping time in rats at 400 mg/kg
Cayman Chemical ANTIBODY IbIglustat 50mg
A GlcCer synthase inhibitor; reduces Gb3 and lyso-Gb3 accumulation in a variety of tissues in the Gla-/- mouse model of Fabry disease; reduces the latency to paw withdrawal in the hot plate test in the same model; reduces gliosis, delays the onset of ataxia, and increases lifespan in the transgenic 4L;C* mouse model of neuronopathic Gaucher disease at 0.03% w/w in the diet
Medchemexpress LLC BMS-37 | 1675202-20-6 | C27H32N2O4 | 25 MG
BMS-37 is a PD-1/PD-L1 immune checkpoint inhibitor with an IC50 towards the PD-L1/PD-1 complex ranging from 18 to 200 nM. It exhibits unspecific toxicity against modified Jurkat T cells with an EC50 between 3 and 6 μM. It can be utilized for studying PD-L1-induced exhaustion of T-cells or as a PD-L1 ligand for synthesizing PROTAC molecules.
- PD-1/PD-L1 immune checkpoint inhibitor.
- Can be used for the study of PD-L1-induced exhaustion of T-cells.
- Can be used as a PD-L1 ligand to synthesize PROTAC molecules.
Medchemexpress LLC 2-Furancarboxamide, 5-cyano-N-(2,5-di-1-piperidinylphenyl)- | 959626-45-0 | 99.6% | 378.47 | 10 MG
cFMS Receptor Inhibitor IV is a chemical compound primarily used for research purposes. It is characterized by its light yellow to yellow solid appearance and high purity, consistently meeting specified quality standards.
- High purity (99.61% by LCMS)
- Light yellow to yellow solid appearance
- Suitable for research applications
- Specific storage conditions for optimal stability
Medchemexpress LLC HY-126303C 5mg Medchemexpress, GS-443902 (trisodium) CAS:1355050-21-3 Purity:>98%
Medchemexpress, HY-126303C 5mg GS-443902 (trisodium) CAS:1355050-21-3 GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Gsk-3β inhibitor 22 | 1005199-84-7 | 99.38% | 423.43 | 5 MG
GSK-3β inhibitor 22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM. GSK-3β inhibitor 22 has the potential of the study of Alzheimer's disease.
- GSK-3β inhibitor with an IC50 of 3.1 nM.
- Potential for the study of Alzheimer's disease.
Medchemexpress LLC Mtx-23 (protac AR-V7 degrader-2) | 2488296-74-6 | 99.79% | 882.05 | 1 MG
MTX-23 is an AR-based PROTAC that inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. It induces apoptosis, offering a potential therapeutic approach for androgen receptor-related cancers.
- AR-based PROTAC
- Inhibits CaP cellular proliferation
- Degrades AR-V7 and AR-FL
- Induces apoptosis
Medchemexpress LLC LY3522348 (KHK-IN-3) | 2568608-48-8 | 98.3% | 409.41 | 1 ML
KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. It can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes, and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation.
- Ketohexokinase (KHK) inhibitor
- Used in the study of kidney disease
- Used in the study of nonalcoholic steatohepatitis (NASH)
- Used in the study of diabetes
- Used in the study of heart failure
- Inhibits the rate-limiting enzyme KHK in fructose metabolism
- Catalyzes phosphorylation of fructose to fructose-1-phosphate
- For research use only
Medchemexpress LLC CP681301 | 865317-32-4 | 99.13% | 298.38 | 500 MG
CP681301 is a potent CDK5 inhibitor exhibiting antiproliferative activity. It effectively decreases the expression of CD133, OLIG2, SOX2, KI67, and pCDK5 protein levels in Glioma stem cells (GSCs). This compound also reduces self-renewal in mouse glioma xenografts and shows anti-tumor activity in Drosophila.
- Potent CDK5 inhibitor
- Shows antiproliferative activity
- Decreases expression of CD133, OLIG2, SOX2, KI67, and pCDK5 protein level in GSCs
- Reduces self-renewal in mouse glioma xenografts
- Demonstrates anti-tumor activity in Drosophila
- Variably cytotoxic effects on GSC cultures
- Not toxic to normal human neuro-progenitors (NHNPs)
- Suppresses CREB Ser133 phosphorylation expression
- Increases median survival in Drosophila models
Medchemexpress LLC GSK-J4 | 1373423-53-0 | 99.45% | 417.50 | 50 MG
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC50s of 8.6 μM and 6.6 μM respectively. This cell-permeable proagent of GSK-J1 induces endoplasmic reticulum stress-related apoptosis and inhibits LPS-induced TNF-α production in human primary macrophages.
- Potent dual inhibitor of H3K27me3/me2-demethylases
- Inhibits LPS-induced TNF-α production in human primary macrophages
- Cell-permeable proagent
- Induces endoplasmic reticulum stress-related apoptosis
- Increases total nuclear H3K27me3 levels in untransfected cells
- Reduces Jagged-1 mRNA and protein levels
- Promotes differentiation of Treg cells