Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,816 – 4,830 of 60,549 results

4,816

TARGETMOL CHEMICALS INC TORKINIB 50MG

Also available in 5 mg 10 mg 25 mg 100 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50 8 nM). It also inhibits mTORC1/2 (IC50s 30/58 nM). purity: 99%

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4,817

Medchemexpress LLC H-Gly-Leu-Phe-OH | 103213-38-3 | 99.4% | 335.40 | 5 MG

H-Gly-Leu-Phe-OH (GLF) is an immunostimulatory tripeptide derived from α-lactalbumin. It inhibits anticancer agent Etoposide-induced alopecia, epidermal thickening, and thinning of the adipocyte layer. This product is intended for research use only.

Immunostimulatory tripeptide
Derived from α-lactalbumin
Inhibits etoposide-induced alopecia, epidermal thickening, and thinning of the adipocyte layer
For research use only
EC50: 0.28 mM for activation of human PEPT1 expressed in MDCK cells
IC50: 0.98 mM for binding affinity to human PEPT1 assessed as inhibition of [14C]Gly-Sar uptake in MDCK cells

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4,818

Cayman Chemical CAY10722, Purity: ≥98%, CAS: 388086-13-3, 10 mg

An inhibitor of SIRT3, a class III HDAC (71% inhibition at 200 µM)

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4,819

Medchemexpress LLC HY-D0023 500mg , Pyranine CAS:6358-69-6 Purity:>98%

HY-D0023 500mg Pyranine CAS: 6358-69-6 Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu+ ion(λex=450 nm, λem=510 nm). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,820

Cayman Chemical H3B-6527, Purity: ≥98%, CAS: 1702259-66-2, 10 mg

An FGFR4 inhibitor (IC50 = 50s = 320, 1,290, and 1,060 nM, respectively), as well as TAOK2, JNK2, and CSF1R (IC50s = 690, >10,000, and >10,000 nM, respectively); decreases cell growth (GI50 = 25 nM) and increases caspase-3/7 activity in Hep3B HCC cells; selectively inhibits cell growth in HCC cell lines that express high levels of FGF19; reduces tumor growth in a Hep3B HCC mouse xenograft model at 100 and 300 mg/kg

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4,821

Medchemexpress LLC IL-11R alpha Mouse 10ug

Recombinant mouse interleukin-11 receptor subunit alpha (IL-11Rα), expressed in HEK293 cells with a polyhistidine tag, provided as a research reagent for studies of IL-11 signaling, receptor binding, and biochemical assays. The sequence corresponds to amino acids S24-Q367 (accession Q64385). Endotoxin is controlled and storage and reconstitution guidance are provided with the product.

Recombinant mammalian expression for native-like post-translational modifications.
Includes a C-terminal His tag to facilitate purification and detection.
Covers amino acids S24-Q367 corresponding to the extracellular domain.
Low endotoxin level suitable for cell-based assays.
Approximate molecular weight 40-55 kDa by SDS-PAGE.
Stable at -20°C for long-term storage; reconstitution guidance provided.

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4,822

Medchemexpress LLC HY-111373 1mg Medchemexpress, RapaLink-1 CAS:1887095-82-0 Purity:>98%

Medchemexpress, HY-111373 1mg RapaLink-1 CAS:1887095-82-0 RapaLink-1, the third-generation bivalent mTOR inhibitor, combines Rapamycin with MLN0128 (a second-generation mTOR kinase inhibitor) by an inert chemical linker. RapaLink-1 shows better efficacy than Rapamycin or mTOR kinase inhibitors (TORKi), potently blocking cancer-derived, activating mutants of mTOR. RapaLink-1 can cross the blood-brain barrier. RapaLink-1 binding to FKBP12 results in targeted and durable inhibition of mTORC1. RapaLink-1 plays an antithrombotic role in antiphospholipid syndrome by improving autophagy. Anticancer activity[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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4,823

Cayman Chemical L-Abrine, Purity: ≥98%, CAS: 526-31-8, 100 mg

A methylated derivative of L-tryptophan; promotes growth in rats fed a tryptophan-deficient diet; unlike tryptophan, it does not affect sleep or wakefulness in rats; serum levels are decreased in patients after an acute ischemic stroke; increased urine levels have been used as a biomarker for abrin poisoning

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4,824

Medchemexpress LLC VU0424465 50mg | 1428630-85-6 | 50 MG

VU0424465 is a research small molecule characterized as a potent, partial positive allosteric modulator (PAM)-agonist of the metabotropic glutamate receptor 5 (mGlu5). It is supplied for laboratory research use only and is not intended for human consumption.

High reported purity of 99.84%.
Molecular weight 326.36 g/mol.
Chemical formula C19H19FN2O2.
Available in small pack sizes such as 50 mg for assay development.
Suitable for pharmacology and medicinal chemistry research.

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4,825

Cayman Chemical STING Agonist D61, Purity: ≥95%, CAS: 2850251-27-1, 5 mg

A STING agonist; induces expression of an IFN3-inducible SEAP reporter gene and an IFN-β-inducible reporter gene in cell-based assays (EC50s = 52.9 and 116 nM, respectively); increases the expression of mRNA encoding IFN-β and CXCL10 and phosphorylation of TBK1, IRF3, and STING in THP-1 monocytes at 4, 6, and 8 µM; reduces tumor volume without affecting body weight in a CT26 murine colon cancer model at 0.25 mg/kg every other day

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4,826

Cayman Chemical MM-206, Purity: ≥98%, CAS: 1809581-87-0, 10 mg

A STAT3 inhibitor (IC50 = 1.16 µM); inhibits G-CSF-induced STAT3 phosphorylation in HL-60, Kasumi-1, and MOLM-13 AML cells (IC50s = 0.8, 1.9, and 1.1 µM, respectively); slows disease progression and improves survival in an AML mouse xenograft model (30 mg/kg per day)

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4,827

Enzo Life Sciences Ro 41-5253 (25mg). CAS: 144092-31-9

A selective RARα antagonist (concentration required to inhibit 50% of specific retinoic acid binding: RARα, 60 nM; RARß, 2400 nM; RARτ, 3300 nM). Counteracts the effects of retinoic acid on HL-60 cell differentiation, B-lymphocyte polyclonal activation and in a RARα transactivation assay. Ro 41-5253 suppresses retinoic acid-induced connexin 43 protein expression in 10T1/2 cells. Purity: ≥98% (TLC). Solubility: Soluble in DMSO (50mg/ml) or 100% ethanol (15mg/ml, warm). Long Term Storage: -20°C.

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4,828

Medchemexpress LLC NIK-IN-2 | 1202763-91-4 | C20H22N4O3 | 5 MG

NIK-IN-2 is a potent inhibitor of NF-κB-inducing kinase (NIK) with a pIC50 of 7.4. It is an alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase, playing an important role in cancer research.

Potent inhibitor of NF-κB-inducing kinase (NIK)
pIC50 of 7.4
Alkynylpyrimidine-based covalent inhibitor
Appears as a white to light yellow solid
Purity of 99.00%
Soluble in DMSO (33.33 mg/mL)
Inhibits NIK in human HT-29 cells with an IC50 of 0.02 μM

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4,829

Cayman Chemical Naphthofluorescein, Purity: ≥98%, CAS: 61419-02-1, 5 mg

A cell-permeable inhibitor of furin (IC50 = 12 μM); inhibits furin-mediated cleavage of the pro-form of MT1-MMP, resulting in decreased levels of active MT1-MMP; inhibits the invasion of Matrigel by the human fibrosarcoma cell lines HT1080

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4,830

Medchemexpress LLC IRBP(651-670) human, mouse | 1977546-93-2 | 99.13% | 2107.32 | 5 MG

IRBP (651-670) human, mouse is an epitope and uveitis inducer naturally processed from the conserved region of native IRBP. It increases the levels of proinflammatory cytokines in ocular tissues (IL-1β, IL-6, TNFα, IL-17A, and IL-17F). This fragment is conserved among human, mouse, and bovine species, and induces experimental autoimmune uveitis, making it applicable to related research.

Epitope and uveitis inducer
Increases proinflammatory cytokine levels (IL-1β, IL-6, TNFα, IL-17A, IL-17F)
Conserved among human, mouse, and bovine species
Induces experimental autoimmune uveitis
White to off-white solid
Soluble in DMSO (100 mg/mL) and H₂O (2.5 mg/mL)
Soluble in PBS (0.5 mg/mL) for in vivo studies
Powder storage at -80°C for 2 years or -20°C for 1 year
In solvent storage at -80°C for 6 months or -20°C for 1 month

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Bioactive Small Molecules

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Medchemexpress LLC H-Gly-Leu-Phe-OH | 103213-38-3 | 99.4% | 335.40 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-D0023 500mg , Pyranine CAS:6358-69-6 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC IL-11R alpha Mouse 10ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-111373 1mg Medchemexpress, RapaLink-1 CAS:1887095-82-0 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC VU0424465 50mg | 1428630-85-6 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NIK-IN-2 | 1202763-91-4 | C20H22N4O3 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC IRBP(651-670) human, mouse | 1977546-93-2 | 99.13% | 2107.32 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More